Study conducted by [154] showed that a melanin-rich strain of the fungus Cladosporium cladosporioides biosorbed 2.5- to 4-fold more Ni, Cu, Zn, Cd, and Pb ion than non-melanic Penicillium digitatum. Bettinger et al. WebMelanin: The Chemical Keys to Black Greatness (Vol. Feb 19, 2023. The melanin produced by A. bridgeri was evaluated in vitro cytotoxicity assay using cell lines TE 355.Sk derived from normal human skin fibroblasts and HEK-293 derived from human embryonic kidney cells, and no cytotoxicity was observed against the two cell lines [103]. Melanin is a substance in the skin that produces skin pigmentation. 2 (2012): 202-11,https://doi.org/10.1016/j.taap.2012.08.002. As shown in Table1, some fungal species produce a dark-brown pigment, known as melanin. We observed that, in the presence of 0.2% corn steep liquor, an increase in the pigment production occurred, while a high yield of biomass was obtained at a concentration of 2%. In recent years, the electronics industry has been driven to develop materials and components that are cheaper and more environmentally friendly. 17. pheomelanin. Licensee IntechOpen. Publishing on IntechOpen allows authors to earn citations and find new collaborators, meaning more people see your work not only from your own field of study, but from other related fields too. It has taken me 10 years of heavy research and application to be able to bring you this information. Hairlessness would have increased our ability to produce vitamin D, an essential component for neurological development and the neuroplasticity and interconnectivity essential for intelligencenot to mention for the stability of our entire genome. Want to read. To date our community has made over 100 million downloads. [113] reported that treatment of macrophages activated in vitro with melanin from the fungus F. pedrosoi inhibited the production of nitric oxide and Th1 cytokines. Goodman and Bercovich, Melanin Directly Converts Light for VertebrateMetabolic Use, 190-202. This book, is designed to familiarize the Black Human with Melanin and its importance to life, memory processes, ancient African history, sunlight, music, dancing, anti-aging, anti-cancer, religion, electromagnetism, and any other scientific and cultural parameters. WebMAGICKAL HOODOO VOODOO HEALING SUPERFOODS. Medical treatments using radiation such as external beam radiation therapy for cancer patients can damage bone marrow resulting in debilitating side effects. Experimental evidence shows that the accumulation of 90Sr by conidia or mycelium by a range of microfungal species is greater in pigmented than in unpigmented species [158]. The optical and electronic properties of melanin have attracted the attention of researchers for the production of continuous thin films from conventional synthetic melanin, which have been used for a number of different device configurations, including chemi-sensors, next-generation solar cells, and a range of other detectors [126, 130, 134]. Wheat bran extract, L-tyrosine, and CuSO4 represent the best combination of medium components to obtain the maximum melanin yield from the fungus A. auricula in submerged culture [73]. WebLiving Color is the first book to investigate the social history of skin color from prehistory to the present, showing how our body's most visible trait influences our social interactions in profound and complex ways. Radionuclide contamination also led to a change in fungal communities, with an increased proportion of melanized fungi. 25. Studies developed in our laboratory, using a melanin-overproducing mutant (MEL1) from Aspergillus nidulans fungus, showed that the higher production of pigment occurred at incubation temperature of 28C compared to 37C [50]. It has also been reported that melanin thin films possess highly desirable physical and biological properties that make them ideal for organic bioelectronic devices [130]. The probable mechanisms of radioprotection by melanin appear to be modulated in pro-survival pathways, immune system, and prevention of oxidative stress. From the ink of the octopus to the protective colorings of bacteria and fungi, melanin offers protection against a variety of biochemical and predatory threats and chemical stressors, and, most famously, acts as a photoprotective factor againstultraviolet radiation. Polymerization of exogenous substrates in this fungus occurs under the action of laccase [19]. The chelating power of fungal melanin can be explained by various functional groups present in the structure of this pigment, which provide an array of multiple nonequivalent binding sites for metal ions [14, 22]. Several studies have shown that the composition of the growth medium, nature and concentration of carbon and nitrogen sources, minerals, vitamins, temperature, pH, the presence of oxygen and aeration, light, stress, and irradiation, among others, affect the growth and pigment production in fungi and that the manipulation of the culture conditions can result in enhanced pigment production [4147]. Considering the harmful effects of synthetic dyes on human health and to the environment, developmental process for obtaining pigments from natural sources has become significant worldwide. By supporting creators you love on Patreon, you're becoming an active participant in their creative process. The fungi grown under red light have no effect, and green or yellow light resulted in worsening effect in all the fungi, thus postulating the existence of photoreceptors responsive to dark and light in all the fungi. These nanoparticles displayed excellent antifungal properties toward an Aspergillus sp. In this pathway, there are two possible starting molecules, L-dopa and tyrosine. 1: the Great Oracle of Tehuti and the Egyptian System of Spiritual Cultivation by Ra Un Nefer Amen 2017 The Author(s). The A. auricula melanin displayed inhibitory activity on biofilm formation of the three bacterial strains, E. coli K-12, Pseudomonas aeruginosa PAO1, and P. fluorescens P-3, and there was a proportional reduction in biofilm biomass with the increase in pigment concentration. The production of DOPA-melanin has also been investigated in other fungi such as Neurospora crassa [94], Podospora anserina [95], A. nidulans [91], A. oryzae, and C. neoformans [96]. 306 ratings 30 reviews. Home > Without adequate vitamin D, our genome would completely destabilize, and immune balance would become disturbed, so the reduction of melanin to augment vitamin D status likely saved the lives of humans who migrated to cooler climates. Capture a web page as it appears now for use as a trusted citation in the future. The melanin-silver nanostructures with broad-spectrum antimicrobial activity against food pathogens also have potential applicability in food processing and food packaging industries [124]. There is experimental evidence that fungal melanin may also act as an anti-aging drug, due to its action in reducing the generation of free radicals, clearing away the free radicals produced in excess, and enhancing the activities of antioxidant enzymes. creating Mind Altering, DNA Re-Ordering Educational Videos!!! These authors also studied the culture of C. cladosporioides in different growth times and found that a culture grown for two days is not pigmented and has only 34% of Cd adsorption rate that obtained for pigmented biomass after 4 days of growth [155]. Some fungal species produce a dark-brown pigment, known as melanin, by oxidative polymerization of phenolic compounds, such as glutaminyl-3,4-dihydroxybenzene (GDHB) or catechol or 1,8-dihydroxynaphthalene (DHN) or 3,4-dihydroxyphenylalanine (DOPA). I have summarised and bulletpointed his main points. One partial explanation for its seeming supernatural capability is that the animals pecten, which is found enlarged in migrating birds who are subject to stressors such as hunger, thirst, hypoxia, and gravity, help the albatross contend with the elements by mediating the melanin-driven conversion of light to metabolic energy. This chapter presents a comprehensive discussion of the research on fungal melanin, including the recently discovered biological activities and the potential use of this pigment for various biotechnological applications in the fields of biomedicine, dermocosmetics, materials science, and nanotechnology. Studies have demonstrated that the promoting or repressing effect of a nitrogen source on pigment production is strain dependent. Melanin is a biological molecule associated with pigmentation in humans and animals. 100% Health cracked, 100% Universal Laws (operating here cracked, how to take advantage), In 100% describes Biblical Law of Jesus Christ which operates in this reality and leads According to Dr Timothy Moore In humans, melanin is the primary determinant of skin and hair colour The biosynthetic pathway of fungal dihydroxynaphthalene(DHN)-melanin. Microbial pigment production is now one of the emerging fields of research due to its potential for various industrial applications, as foodstuff, cosmetics, pharmaceutical, and textile manufacturing processes. 103 pages, Paperback Published September 1, 2001 Another study of the biocompatibility of melanin thin films demonstrated that the melanin film effectively supports the growth of undifferentiated stem cells and their differentiation into neuronal precursors and neurons [146]. Several biological functions of melanins are closely associated to their chemical composition and structure. WebK12 School Digital and Curricular Classroom Materials - NGL This will also allow me to purchase better equipment to produce higher quality videos to learn from! In order to compensate for the decreased availability of sunlight, the human body rapidly adjusted, potentially removing the natural sunscreen, melanin, from the skin since it interferes with the production ofvitamin D, a hormone that participates in governing the expression of more than 2,000 genes. 2,799 views May 25, 2018 163 Dislike Share REEL NAGAS 28.5K subscribers Order Your Copy of the Great Book of Melanin Research Today!!! WebGREAT BOOK OF MELANIN RESEARCH PUBLIC OFFICIAL BONDS BOOK (POB) Public Official Bonds - Make Them Pay!!! The Management of Quality in Construction, Political Science. Due to a planned power outage on Friday, 1/14, between 8am-1pm PST, some services may be impacted. Scientists have identified three forms of melanin in humans: eumelanin. Amazon.com: Melanin Research Foundation: Books 1 result RESULTS Melanin: Energy from Light and the Soul's Ascent by Melanin Research Foundation | May 3, 2015 20 Kindle $399$6.12 Available instantly Paperback $612 FREE delivery Sat, Dec 10 on $25 of items shipped by Amazon Need help? 4.37. This result is related to melanin production during growth of the MEL1 mutant, since the biomass 48 hours is slightly pigmented, while the 72 hours biomass is dark due to the increased production of pigment [157]. It has been reported that melanin contributes for virulence of C. neoformans, protecting the pathogen against free radicals generated immunologically [29]. Packed with knowledge of the food of the gods. In experimental models, melanin can successfully shield bone marrow from such side effects. Print length 103 pages Language English Publisher Lushena Books Publication date Lora Mangum Shields, L. W. Durrell, and Arnold H. Sparrow,Preliminary Observations on Radiosensitivity of Algae and Fungifrom Soils of the Nevada Test Site,Ecology42, no. The excess free radicals may attack cellular constituents, as the cell membrane, nucleic acid, protein, enzymes, and other biomolecules, by peroxidation, resulting in the severe damage of cell functions and subsequent serious deleterious effects on the organism [106]. A biosynthesis pathway for fungal DOPA-melanin, proposed by [11], is shown in Figure2, which strongly resembles the pathway found in mammalian cells, though some of the details may differ. In the Ascomycota fungi, melanin pigment is generally synthesized from the pentaketide pathway in which 1,8-dihydroxynaphthalene (DHN) is the immediate precursor of the polymer, as described by Bell and Wheeler [11] based on genetic and biochemical evidence obtained from Verticillium dahliae and W. dermatitidis [84, 85]. @DESIRE | You #Enslave or are-Enslaved. Apart from the scavenging activity, melanin exhibits other biological activities, including thermoregulatory, radio- and photoprotective, antimicrobial, antiviral, cytotoxic, anti-inflammatory, and immunomodulatory. This effect was observed for Cryptococcus neoformans, whose in vitro melanization has been associated with resistance against host effector cells, oxidants, microbicidal peptides, and amphotericin B [2325], and in Wangiella (Exophiala) dermatitidis, when the polyketide synthase gene WdPKS1 associated on melanin production was disrupted, this strain has become more susceptible to voriconazole and amphotericin B [26]. In M. ruber, the use of glutamic acid as a nitrogen source showed promising results, either as stimulating the accumulation of extracellular pigments or contributing to increase the efficiency of the pigment production process [45]. The probable mechanism of action was suggested by a study published inBioelectrochemistry,30in which ionizing radiation was found to alter melanins oxidation-reduction potential. In Melanin, the Master Molecule, researchers summarize several decades worth of knowledge on melanin and its physicochemical properties. Studies have shown that one of the major causes of aging is the surplus free radicals produced during the oxidative metabolism in the human body [108]. Dopaquinone, a highly reactive intermediate, forms leucodopachrome, which is then oxidized to dopachrome. A. Kunwar et al., Melanin, a Promising Radioprotector: Mechanisms of Actions in a Mice Model,Toxicology and Applied Pharmacology264, no. About the author. WebThe book features nearly all unknown secrets. Sign up for their newsletter here. It has been reported that melanin protects melanocytes and keratinocytes from the induction of DNA strand broken by hydrogen peroxide, indicating that this pigment also has an important antioxidant role in the skin [107]. *Address all correspondence to: sponchia@iq.unesp.br. Book details & editions. In cosmetic industry, there are great interests in the melanin, especially to protect against the noxious effects of UV radiation by incorporation in skin photoprotection formulations [35, 148]. WebThis volume goes over the brain hemispheres, history of religion, Black founders of civilization, the Sun, cosmology and cosmogony, the subjective and objective realms of being, analysis of cosmological system and view of man, spiritual anatomy of man, types of man and the cultivation of the spiritual man, the Tree of Life initiation system, Others studies suggest that melanin contributes to fungal pathogenesis because this pigment alters the host defense response mechanisms, decreases phagocytosis, and reduces the toxicity of microbicidal peptides, reactive oxygen species, and antifungal drugs as well as to play a significant role in fungal cell wall mechanical strength [27, 28]. Impressively, however, 90 percent of the mice that had been given melanin-richmushroomsor white mushrooms supplemented with melanin survived.29. The first known organic semiconductor,15it is a black substance prominent in eyes, skin, hair, scales, and feathers, and it can also be found in the mammalian central nervous system. Sheng Meng and Efthimios Kaxiras. These advances allow to elucidate the molecular mechanisms of the various biological functions of melanin [22]. Brief introduction to this section that descibes Open Access especially from an IntechOpen perspective, Want to get in touch? The production of devices based on thin film melanin exhibited electrical conductivity comparable to that of amorphous silicon [130]. The rapid expansion of our speciess brain volume, known as encephalization, occurred at the same time as the adaptive event of human hair loss, around 2 million years ago. To that of amorphous silicon [ 130 ] in melanin, the electronics industry has been reported melanin. 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