(In-vitro Swedish Study) https://youtube.com/live/MjxlvduyJyc?feature=share 28 Feb 2023 02:39:58 Its See here for a complete list of exchanges and delays. We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure. Whether the findings of the study will occur in living organisms or if the DNA converted from the vaccines mRNA will integrate with the cells genome is unknown. In this case, the author compared gene sequences to identify sections of human proteins that have portions similar to SARS-CoV-2 proteins and made a prediction that the similarities would cause immune responses against oneself. CLAIM: A Swedish study shows that Pfizers COVID-19 vaccine changes recipients DNA. Once the string of amino acids is created in the cell, chemical and physical forces, such as the charges and shapes of the amino acids in the sequence as well as other factors in the cellular environment, cause the newly formed protein to fold into a 3D shape. The product has been, During the foetal stage, a number of so-called cell programs run that are vital to the development of the foetus. doi: 10.1056/NEJMc2107717. In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro. eCollection 2022. Why liver cells and why the specific dose? 5. The experiment was conducted in a petri dish and aimed to answer the question of whether the mRNA in the vaccine could be converted to DNA. Please enable it to take advantage of the complete set of features! Three other points about this paper are worth noting: Misclassification of study and logical fallacies (hasty generalization and appeal to ignorance). The approval came as an emergency use authorization on December 11, 2020, after clinical trials showed the vaccine was 95% effective in preventing COVID-19. The experiment was conducted in a petri dish and aimed to answer the question of whether the mRNA in the vaccine could be converted to DNA. Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver. YDM: This study does not investigate whether the Pfizer vaccine alters our genome. This three-part series was aimed at describing several important aspects of science. 41.2M. These cells have had the normal protections of the immune system removed.. They have somewhere between 90 to 95% efficacy at providing immunity to someone In thisstudywe present evidence that COVID-19 mRNA vaccine BNT162b2 is able to enter the human liver cell line Huh7 in vitro, the researchers wrote in the study, published inCurrent Issues of Molecular Biology. 1 . DNA amplicons (444 bps) were visualized on agarose gel. The messenger RNA (mRNA) from Pfizer s COVID-19 They used different concentrations of the vaccine and multiple timepoints to measure: Some pointed to this paper as proof that COVID-19 vaccines alter DNA. About BVHS; Mayo Clinic Care Network; News & Media; Contact Us Our monetization model empowers Citizen Journalists to report the news in local and national markets. Its precisely what health experts and fact-checkers said for more than a year could not occur. Drugs and Lactation Database (LactMed) [Internet]. Pfizers COVID trials6 enrolled 46,331 participants in a Phase 3 clinical trial while Recombivax HB tested just 147 infants and children. Unable to load your collection due to an error, Unable to load your delegates due to an error. A new Swedish study published in MDPI found that the Pfizer vaccine goes into liver cells and converts to DNA, challenging claims so far that the mRNA COVID-19 vaccines do not change or interact Data, especially data from vaccinated humans, will hopefully sort out the question marks. Accessibility and Terms of Use. Below Australian experts address this concern Expert Comments: Professor Nigel McMillan Program Director of Infectious Diseases and Immunology at the Menzies Health Institute Queensland , Griffith What are the next steps in this research? Huang X, Kong N, Zhang X, Cao Y, Langer R, Tao W. Nat Med. WebPfizer Vaccine Becomes DNA in Liver Cells. This study of 218 people infected with COVID-19 compared their vaccination status, severity of illness and blood samples. Two different antibody-dependent enhancement (ADE) risks for SARS-CoV-2 antibodies. This will lead to some parts of our website to not work properly or at all. The site is secure. However, we do not guarantee individual replies due to the high volume of messages. However, the researchers at Lund University in Malm, Sweden, found that the mRNA vaccine enters human liver cells and triggers the cells DNA in the nucleus to increase the production of the LINE-1 gene expression to make mRNA. Webhttps://lnkd.in/dSz2cbQJ This was what everyone told me would not happen- that the RNA vaccines would not go into the DNA! Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. The researchers write that the findings warrant a further 2020;383:26032615. The study authors clarified their research in a Q&A in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. Further studies are needed to demonstrate the effect of BNT162b2 on genomic integrity, including whole genome sequencing of cells exposed to BNT162b2, as well as tissues from human subjects who received BNT162b2 vaccination, the authors said. 2022 Dec 9;14(12):e32361. Bookshelf Further proof with COVID-19. By Meiling Lee. No added sugar, full of protein and chocolate! Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. Our results indicate a fast up-take of BNT162b2 into human liver cell line Huh7, leading to changes in LINE-1 expression and distribution. Shakira. Neither your address nor the recipient's address will be used for any other purpose. Before The genetic material delivered by mRNA vaccines never enters the nucleus of your cells, the CDC said on its web page titled Myths and Facts about COVID-19 Vaccines.. Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc. sharing sensitive information, make sure youre on a federal Because the study design does not necessarily reflect what happens in most human bodies, he said the findings cannot be extrapolated to make inferences about what would happen in human subjects. 2021 Jun 7;22(5):172. doi: 10.1208/s12249-021-02058-y. Huh7 cells were treated without (Ctrl) or with 0.5, 1, and 2 g/mL of BNT162b2 for 6 h. Cells were fixed and stained with antibodies binding to LINE-1 ORF1p (red) and DNA-specific probe Hoechst for visualization of cell nucleus (blue). Likewise, even if these data were found to be representative of ones ability to spread the virus, it is not appropriate to dismiss the rest of the curve, which shows differences between vaccinated and unvaccinated people after day four or five. 41.1M. Would you like email updates of new search results? The researchers write that the findings warrant a further -, Walsh E.E., Frenck R.W., Jr., Falsey A.R., Kitchin N., Absalon J., Gurtman A., Lockhart S., Neuzil K., Mulligan M.J., Bailey R., et al. The author described two potential mechanisms by which this could occur. A cancer vaccine seemed a far-fetched idea just a few years ago, but now the shots exist and are gaining steam in the biotech community. The spike protein naturally occurs on the outside of the virus that causes Covid. This also explains the choice of vaccine concentrations in our study, something we specifically address in the paper, which are 0.52% of the injection site concentration. Associate Professor or, by Lund University. Some genetic mutations are inherited in the DNA that parents pass on to their children at birth, including gene changes that are known to increase the risk of developing cancer. They used different concentrations of the vaccine and Keywords: The. 5. WebPfizer Vaccine Becomes DNA in Liver Cells. [(accessed on 22 February 2022)]. -, Harris R.J., Hall J.A., Zaidi A., Andrews N.J., Dunbar J.K., Dabrera G. Effect of Vaccination on Household Transmission of SARS-CoV-2 in England. The data represent RNA levels not viral particles, so while the patient samples required equal cycles of PCR to detect RNA, we cant speak to a persons contagiousness because this study does not tell us how much whole virus was present in their nasal passages. YDM: One of the limitations of our study is that we don't know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. Let's review.\r\rIf you like this content and want more, I am doing a special lifetime membership offer. Whether our results are true for other cell types in humans, or if they are specific to mRNA vaccines, are among many questions for further research. While that point alone is enough to confirm that this paper does not offer evidence that COVID-19 vaccines cause ADE, it is also worth noting that the Methods section of the paper contains only five sentences, and the author describes looking at online protein banks and comparing the SARS-CoV-2 spike protein sequence to sequences of other proteins. Epub 2022 Feb 3. And, while this may be the case early during infection, there are a few additional considerations when thinking about these data: Hopefully these examples demonstrated some of the ways that a paper should be examined. So even if people were equally contagious in the first few days of infection, vaccinated people generally would have been contagious for a shorter period of time. BNT162b2 mRNA levels in Huh7 cells treated with BNT162b2. Ricke DO. 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