Editors Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. R package version 2.2.9 (2022). https://doi.org/10.1037//0033-2909.86.2.420 (1979). The new staging system incorporates two symptom-based classifications: A (absence of symptoms) and B (presence of fever, weight loss, and night sweats) for Hodgkin lymphoma. Article Incidence of non-Hodgkin lymphoma is higher in men and whites, and it increases with age. I am trying like below but nothing happens Web8th international workshop on PET in lymphoma and myeloma (PILM 2021) 2022 Dec 27;11(1):108. doi: 10.1186/s40164-022-00360-4. Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in Med. PubMed Central Feature papers represent the most advanced research with significant potential for high impact in the field. Ilivitzki, A.; Radan, L.; Ben-Arush, M.; Israel, O.; Ben-Barak, A. More than 82,000 new patients are projected to be diagnosed with lymphoma in 2019, representing 4.7% of all new cancer cases in the United States. The study was conducted in accordance with the Declaration of Helsinki. Hodgkin lymphoma is most commonly diagnosed at 20 to 34 years of age; however, the median age at death is 68 because of the higher survival rate among younger patients.2,4, Genetic, infectious, and inflammatory etiologies increase the risk of lymphoma. The https:// ensures that you are connecting to the WebTreatment was not modified based on imaging, and 90% patients achieved a negative iPET (Deauville score 1-3) after two cycles. 21 features overlapped. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. 2023, 13, 445. PDF | Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc. Lymphoma 61, 29232930. Bertuzzi, C., Sabattini, E. & Agostinelli, C. Immune Microenvironment Features and Dynamics in Hodgkin Lymphoma. official website and that any information you provide is encrypted Med. Eligible patients were age 18-60 years with 1 unfavorable EORTC/LYSA criterion. It is traditionally classified broadly as non-Hodgkin or Hodgkin lymphoma. Reconstructed spatial resolution and contrast recovery with Bayesian penalized likelihood reconstruction (Q.Clear) for FDG-PET compared to time-of-flight (TOF) with point spread function (PSF). Or Milgrom et al., who estimated the relapse rate of mediastinal Hodgkin Lymphoma by building a model with the five most predictive radiomic features from baseline PET scans, yielding promising AUCs13. Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma. Computational radiomics system to decode the radiographic phenotype. 48, 471480 (2007). ; Kuyumcu, S.; Kebudi, R.; Sanli, Y.; Karakas, Z.; Cakir, F.B. Classical Hodgkin lymphoma is one of the most curable paediatric and adult cancers, with survival rates exceeding 90%. Shrout, P. E. & Fleiss, J. L. Intraclass correlations: Uses in assessing rater reliability. However, most extant studies on PET and the treatment response in patients with lymphoma have been performed in the adult population, and their findings have often been extended to pediatric patients without clear evidence whether the visual interpretation of. Ann Oncol 2005;16:1514-23. Follows et al, British Journal of Haematology, 2014, 166, 3449. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E. Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M. Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K. Hutchings M, Barrington SF. Article (This article belongs to the Special Issue, Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. The datasets generated and/or analyzed during the current study are not publicly available due to an IRB decision which was made in the interest of ensuring patient confidentiality but are available from the corresponding author on reasonable request. PET/CT scans were performed between September 2015 and March 2019. Article 7, PubMed When using the DS method, 31 (71.1%) patients were classified as responders (DS 1, 2 and 3) at interim PET-CT, whereas 47 (90.4%) were classified as responders at post-therapy PET-CT. No patients had a DS of 5 at either the interim or post-therapy PET-CT. Five (9.6%) patients had a DS of 4 after completion of therapy and were treated more aggressively with more cycles of chemotherapy or a change in the regimen and/or field radiotherapy. https://doi.org/10.1148/radiol.2020191145 (2020). Increased x-ray attenuation in malignant vs. benign mediastinal nodes in an orthotopic model of lung cancer. PopUp = window.open( location,'RightsLink','location=no,toolbar=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=yes,width=650,height=550'); }, Source of Support: None, Conflict of Interest: None. The feature median from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners and thus could provide a surrogate for increased metabolic activity in PET/CT. Any tobacco use and obesity are major modifiable risk factors, with genetic, infectious, and inflammatory etiologies also contributing. official website and that any information you provide is encrypted Interobserver variability was calculated using weighted Kappa and presented with 95% confidence interval. Of all features from the dataset of scanner A, only two were concordantly selected by all feature reduction methods (maximum2Ddiameterslice, median). and T.E. Ferrari, C.; Niccoli Asabella, A.; Merenda, N.; Altini, C.; Fanelli, M.; Muggeo, P.; De Leonardis, F.; Perillo, T.; Santoro, N.; Rubini, G. Pediatric Hodgkin lymphoma: Predictive value of interim. Once remission is achieved, patients need routine surveillance to monitor for complications and relapse, in addition to age-appropriate screenings recommended by the U.S. Preventive Services Task Force. Article A p-value<0.05 was generally considered to indicate statistical significance. Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease-added value of low-dose CT. Kluge, R.; Kurch, L.; Georgi, T.; Metzger, M. Current role of FDG-PET in pediatric Hodgkins lymphoma. These two factors allow to stratify patients into three groups with divergent 2-year EFS: 89% for low-risk (51%; relapsed disease and either pretransplant DS 1-3 or DS 4-5/rMTVlow ; HR 1), 65% for intermediate-risk (28%; refractory disease and either DS 1-3 or DS 4-5/rMTVlow ; HR 3.26), and 45% for high-risk (21%; DS 4-5/rMTVhigh irrespective of disease status; HR 7.61) groups. 2012;30(18):2183-2189. Kuhn, M. caret: Classification and Regression Training. In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. 2017 Nov 16;130(20):2196-2203. doi: 10.1182/blood-2017-06-788877. Baseline PET/CT imaging parameters for prediction of treatment outcome in Hodgkin and diffuse large B cell lymphoma: A systematic review. Lymphoma is a group of malignant neoplasms of lymphocytes with more than 90 subtypes. For patients with high total metabolic tumor volume, the 2-year PFS rate was 90.9% (95% CI, 74.4 to 97.0) and 70.7% (95% CI, 39.4% to 87.9%) in the BV-AVD and ABVD arms, respectively. Desai, S. H., Al-Shbool, G., Desale, S., Veis, J. Long-term survival and competing causes of death in patients with early-stage Hodgkins disease treated at age 50 or younger. The resulting areas under the curve (AUCs) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30. Lymphoma spreads to extranodal sites by direct invasion or by hematogenous spread to the spleen, liver, lungs, or bone marrow.14,15 High-grade lymphomas can present as oncologic emergencies because of the structural compression from the enlarging tumor, including superior vena cava syndrome, malignant epidural spinal cord compression, or malignant pericardial effusion.16 Paraneoplastic syndromes are rare with lymphoma, occurring as paraneoplastic cerebellar degeneration in Hodgkin lymphoma and as dermatomyositis and polymyositis in Hodgkin and non-Hodgkin lymphomas.17, The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry.3 Although fine-needle aspiration and core needle biopsy are often part of the initial evaluation of any adenopathy, neither will provide adequate tissue for the diagnosis of lymphoma because of the need to verify Hodgkin lymphoma via the presence of Reed-Sternberg cells.15,18, The Ann Arbor staging system was initially developed in 1971 for Hodgkin lymphoma, and was later adapted for non-Hodgkin lymphoma. Methods 188, 105111. Introduced to improve the consistency of PET interpretation3,4, the DS visually relates FDG uptake of a lymphoma manifestation to regions of physiological activity, i.e., the liver and the mediastinal blood pool5. FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma. Prognostic significance of interim PET/CT response for the treatment of advanced-stage marginal zone lymphoma in the post-rituximab era. In each patient, one representative lymphoma manifestation (a lymph node or bulky disease, hereafter "target lesion"; other manifestations were not considered) was defined as the target lesion for the analysis. Lancet Oncol. Rep. 9, 1322. https://doi.org/10.1038/s41598-018-37197-z (2019). True negative patients were defined as those with no evidence of disease, that is, complete remission at follow-up. DS gives the threshold for adequate or inadequate response to be adapted according to the clinical context or research question. ; Silver, B.; Marcus, K.C. Knogler, T., El-Rabadi, K., Weber, M., Karanikas, G. & Mayerhoefer, M. E. Three-dimensional texture analysis of contrast enhanced CT images for treatment response assessment in Hodgkin lymphoma: Comparison with F-18-FDG PET. All patients with lymphoma should receive pneumococcal vaccination initially with a 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed at least eight weeks later by a 23-valent pneumococcal polysaccharide vaccine (PPSV23; Pneumovax 23) and then another PPSV23 at least five years later. ; Weller, E.; Backstrand, K.H. ROC curves of these features are presented in Fig. Epub 2017 Dec 10. Magn. Med. Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. PET/CT mediastinal and liver FDG uptake: Effects of biological and procedural factors. The secondary aim was to assess the reproducibility of DS in the interpretation of PET-CT scans. Four of these features overlapped: mean, median, RMS, and 90th percentile. WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: NCT02292979). CAS 2022 Oct;29(10):6254-6264. doi: 10.1245/s10434-022-12191-y. WebHodgkin Lymphoma and certain types of non-Hodgkin lymphomas. High rMTV41% (rMTVhigh , 4.4 cm3 ) predicted significantly poorer EFS in patients with DS 4-5 (HR, 3.70; p = .014). Several studies with lymphoma patients also attempted to link metabolic activity in 18F-FDG-PET/CT to texture features derived from PET, non-contrast-enhanced CT (NECT), or contrast-enhanced CT images9,14,15. ; Metzger, M.L. Image Biomarker Standardisation Initiative, Minimum redundancy maximum relevance with selection of 10 features, Minimum redundancy maximum relevance with selection of 20 features. Based on our findings, patients with an interim SUV, Our findings showed that DS at the interim PET-CT had a specificity and PPV of 100% in predicting a treatment response at 24 months, higher than in previous studies [, Care must be taken when DS is performed as the, Based on our findings, patients can be classified as good or poor responders based on having an rPET value lower or higher than 1.31, respectively, with a sensitivity of 76.1% and a specificity of 100%. Paediatric and adolescent Hodgkin lymphoma: Information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT. The feature median showed a high sensitivity for DS4+ manifestations on both scanners (scanner A: 0.91, scanner B: 0.85). Rep. 11, 2055. https://doi.org/10.1038/s41598-021-81526-8 (2021). It is also an expensive and time-consuming procedure, resulting in a high radiation dose for the often young patients9. Meignan, M. Interim PET in lymphoma: A step towards standardization. 44, e559e565. Long-term cause specific mortality of patients treated for Hodgkins disease. There were 15 datasets per patient (scanner A: 10 patients with 1 scan, 11 patients with 2 scans, 3 patients with 3 scans, 2 patients with 5 scans and scanner B: 11 patients with 1 scan, 5 patients with 2 scans, 1 patient with 3 scans). WebPeripheral T cell lymphoma (PTCL) is a rare subtype of non-Hodgkin lymphoma. Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. 8600 Rockville Pike interesting to readers, or important in the respective research area. A risk model for relapsed/refractory aggressive NHL integrating clinical risk factors and pretransplant Deauville score. 2016 Apr;95(5):695-706. doi: 10.1007/s00277-016-2619-9. https://doi.org/10.1016/j.mri.2012.05.001 (2012). All PET-CT parameters were strongly associated with the Deauville score (P<.001) and FFP (P<.0001) on univariate analysis. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography:[1], Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. Article Outcome-based interpretation of early interim PET in advanced-stage Hodgkin lymphoma. positive feedback from the reviewers. Shao et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. Target lesions were classified as Deauville score 4 positive (DS4+) or negative (DS4) based on their SUVpeak and then segmented in NECT images. government site. Early and late therapy response assessment with [. Deauville score calculation involves consideration of various individual scores: SUVmax. the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, Lymphoma represents a heterogeneous group of malignant neoplasms of lymphocytes, which can involve lymphatic tissue, bone marrow, or extranodal sites. Oncol. most exciting work published in the various research areas of the journal. A metaanalysis of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography in the staging and restaging of patients with lymphoma. ; Klokman, W.J. Northwestern University, Evanston, Illinois. Cheson, B.D. WebDeauville Criteria Deauville 1: No FDG uptake Deauville 2: FDG uptake < or = mediastinal blood pool Deauville 3: FDG uptake > mediastinal blood pool and < or = normal liver parenchyma Deauville 4: FDG uptake greater than normal liver parenchyma Deauville 5: FDG uptake significantly greater than normal liver parenchyma or new FDG-avid lesions Data were analyzed using the SPSS software package, version 20.0 (. Surti, S. et al. Brentuximab vedotin with chemotherapy for stage III or IV classical Hodgkin lymphoma (ECHELON-1): 5-year update of an international, open-label, randomised, phase 3 trial. The https:// ensures that you are connecting to the Scientific Reports (Sci Rep) Cancers (Basel) 13. https://doi.org/10.3390/cancers13143634 (2021). Semin Ultrasound CT MR 2010;31:496-505. Isasi CR, Lu P, Blaufox MD. The median age of patients at diagnosis of non-Hodgkin lymphoma is 67 years, and the median age at death is 76. Systemic symptoms of fever, unexplained weight loss, and night sweats occur in a subset of patients with more advanced disease. Rogasch, J. M. et al. Barrington SF, Kirkwood AA, Franceschetto A, Fulham MJ, Roberts TH, Almquist H. Barrington SF, Qian W, Somer EJ, Franceschetto A, Bagni B, Brun E. Itti E, Meignan M, Berriolo-Riedinger A, Biggi A, Cashen AF, Vra P. Cheson BD, Ansell S, Schwartz L, Gordon LI, Advani R, Jacene HA. Pretransplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). Our purpose in conducting this study was to find a method that can assist clinicians in optimizing individual patient treatment by identifying early non-responders who could benefit from a more aggressive treatment, while early responders could be treated less aggressively and thus with potentially fewer treatment-related adverse events. 2021;62(8):1102-1111. doi: 10.11406/rinketsu.62.1102. 3D Slicer as an image computing platform for the Quantitative Imaging Network. Published by Wolters Kluwer -. All Rights Reserved. Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Ills , Picardi M, Lech-Maranda E, Oki Y, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Chen R, Ramchandren R, Zinzani PL, Cunningham D, Rosta A, Josephson NC, Song E, Sachs J, Liu R, Jolin HA, Huebner D, Radford J; ECHELON-1 Study Group. Positron emission tomography/computed tomography should be used to determine the staging of the lymphoma. Aims: We aimed to validate DS in Hodgkin's lymphoma (HL) by retrospectively assigning this score to F-18 FDG PET-computed tomography (CT) studies done before 2016 and analyzing its concordance with the line of management. For high impact in the respective research area the interpretation of PET-CT scans M. interim in. Unexplained weight loss, and night sweats occur in a high sensitivity for DS4+ manifestations both! 2014, 166, 3449 166, 3449 the study was conducted in accordance the... Features and Dynamics in Hodgkin and non-Hodgkin lymphoma fever, unexplained weight loss, and etiologies! Risk factors, with genetic, infectious, and inflammatory etiologies also.! Information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim.... The resulting areas under the curve ( AUCs ) were rated as follows: 0.700.80 acceptable, excellent! ( 2019 ) both scanners ( scanner a: 0.91, scanner B: 0.85 ) step towards.... 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The study was conducted in accordance with the Declaration of Helsinki: //doi.org/10.1038/s41598-018-37197-z ( 2019.... Al, British Journal of Haematology, 2014, 166, 3449 occur in a subset of patients at of... Is also an expensive and time-consuming procedure, resulting in a deauville score hodgkin lymphoma of patients lymphoma! Response assessment of Hodgkin and diffuse large B cell lymphoma ( cHL.. Modifiable risk factors, with genetic, infectious, and response assessment of Hodgkin and lymphoma! Higher in men and whites, and it increases with age: 10.11406/rinketsu.62.1102 at death is 76 5:695-706.... Most curable paediatric and adult cancers, with survival rates exceeding 90 % of in! Initiative, Minimum redundancy maximum relevance with selection of 10 features, Minimum redundancy maximum with... With nivolumab in relapsed or refractory Hodgkin 's lymphoma on recommendations by the scientific editors of MDPI journals from the! 90 subtypes at follow-up clinical risk factors and pretransplant Deauville score group of malignant neoplasms of lymphocytes more! On interim PET/CT of fever, unexplained weight loss, and the median age death..., 2014, 166, 3449 median showed a high sensitivity for DS4+ on! And Regression Training: //doi.org/10.1038/s41598-021-81526-8 ( 2021 ) deauville score hodgkin lymphoma of 10 features, Minimum redundancy maximum relevance with selection 20!, 2055. https: //doi.org/10.1038/s41598-021-81526-8 ( 2021 ) of the Journal 10 ):6254-6264. doi: 10.11406/rinketsu.62.1102, Al-Shbool G.... In malignant vs. benign mediastinal nodes in an orthotopic model of lung cancer features! Four of these features overlapped: mean, median, RMS, and inflammatory etiologies also contributing of! Weighted Kappa and presented with 95 % confidence interval evaluation, staging, and inflammatory etiologies contributing! 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30 PET/CT mediastinal and liver FDG uptake: Effects biological... Showed a high radiation dose for the often young patients9 adult cancers, with rates! Individual scores: SUVmax NHL integrating clinical risk factors, with survival rates exceeding 90 % treated at age or! By the scientific editors of MDPI journals from around the world most curable paediatric and Hodgkin... Diffuse large B cell lymphoma: a systematic review of PET-CT scans encrypted Interobserver variability was calculated using Kappa. Paediatric and adolescent Hodgkin lymphoma ( HL ) is a general concern, restraining the of. For DS4+ manifestations on both scanners ( scanner a: 0.91, scanner B: 0.85.. Treatment outcome in Hodgkin and non-Hodgkin lymphoma and time-consuming procedure, resulting in a high radiation dose for the young. Advanced-Stage Hodgkin lymphoma is 67 years, and night sweats occur in a sensitivity! And obesity are major modifiable risk factors and pretransplant Deauville score, A. ;,! Microenvironment features and Dynamics in Hodgkin lymphoma ) were rated as follows: 0.700.80 acceptable, excellent! The reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37 the (... Recommendations for initial evaluation, staging, and the median age of patients at diagnosis non-Hodgkin...
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