On average, they deal 66% damage. Seeds UNLOCK: Unlock this item by defeating Mother in the Corpse II as ??? "Charged burst attack" This will deviate you from the alt path if you are currently on it, Since this item resets your stats, this item can remove Broken Hearts, UNLOCK: Unlock this item by defeating Greedier Mode as Jacob & Esau, Item Pool: Angel Room, Greed Mode Angel Room, Upon use, allows you to consume 1 key and fire it at an enemy, piercing enemies and dealing significant damage, The damage done by the key projectile pierces through enemies and scales with your damage upgrades (x5 damage + 30), Keys fired by this item can open locked doors/chests, secret rooms and destroy objects in the room, such as rocks, Cannot be used if you don't have any keys, Enemies killed by Sharp Key have a ~10% chance to spawn random items that appear in a chests. white, grey, gray moms pad, mom pad, A poison bomb which can be thrown and leaves a poison effect on any enemies within the blast radius. I do not know what is that secret room, i got the info by using a rune shard, not sure what the voice said when i used the rune. Characters Brimstone is a promotional cosmetic item for all classes.It is based on the horns given by Brimstone in the video game The Binding of Isaac: Rebirth; a pair of curved horns.. The only way to remove broken hearts is by donating to a Confessional Machine, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Jacob & Esau, Holding the fire button charges up a light beam attack similar to Brimstone, The light beam deals damage equal to your current tear damage per tick to any enemies touching it, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Bethany, When picked up, this item gives you a stat increase, based on which is currently the lowest. And just to be clear in case someone doesn't understand: it was a few days after Rebirth release. Seeds This room isn't part of the actual floor, and leaving it returns you to where you teleported from, The boss isn't necessarily from the current floor - e.g. Soy Milk) can lead to interesting synergies, * astrology, astronomy, item room, treasure room, item room pool, ohm, blue, glow, Isaac's tears turn bright green and always apply a poison effect to enemies which deals a total of double your tear damage, This is essentially a superior version of The Common Cold item, * astrology, astronomy, item room, treasure room, item room pool, m, tail, blue, glow, Tears do not travel through rocks with this item, *astrology, astronomy, item room, treasure room, item room pool, nys, notyoursagittarius, Upon hitting the floor, an obstacle, or an enemy they burst into smaller tears in all directions. Item Tags the eternal hearts that drop in angel themed super secret rooms, All heart drops from Ace of Hearts will be Black Hearts, UNLOCK: Unlock this item by beating Satan with Azazel, *, black, devil, pointy, daemons tail, demons tail, demon tail, Dying in a sacrifice room while holding this trinket will unlock The Lost character, After The Lost is unlocked, dying anywhere with this trinket will bring you back to life as The Lost and the trinket will be deleted, When playing as Tainted Lost, you don't swap to being regular Lost, it simply acts as an extra life, UNLOCK: Unlock this item by beating Dark Room with Isaac, Everytime you pick up a coin, you fart, inflicting poison damage to nearby enemies, Greatly increases the chance of coins dropping from poops, Tears now move forwards at right angles, shifting left and right across the room, Increases your range stat by +10.0 while held but due to the fire pattern, your tears travel a similar distance to normal, Your tears now whip across the room at a very high shot speed, Shot speed gives your tears more effective range, but doesn't increase your range stat directly, Has a 22.22% chance to respawn with 3 Soul hearts as Blue Baby when you die, UNLOCK: Unlock this item by beating Satan with Lazarus, Everytime Isaac takes damage, one blue fly will spawn, * , the lost item pool, green, red, bloody, dead, Isaac's tears have a chance to poison enemies, The poison effect leaves a damage over time, which deals 4 or 6 damage per tick, The chance to poison enemies is affected by your luck stat and at +18 Luck it will activate every time, Isaac now has a chance to make a spectral and piercing tear, The chance to fire a piercing tear is affected by your luck stat and at +18 Luck it will activate every time, While held, this trinket gives a random mushroom effect each room, Possible mushrooms include: Mini Mush, Odd Mushroom (Thin), Odd Mushroom (Thick), The Compass, *, ping, pong, paddle, grey, gray, mushroom, While at 1/2 a red heart of health, you gain a Little Steve familiar that follows you and shoots homing tears, REPENTANCE - Umbilical Cord now has a high chance to spawn a Gemini familiar for the room when Isaac takes damage. This item was awarded in Genuine quality to players who purchased The Binding of Isaac . Tears are fired in an arc. REPENTANCE - The Lost's Holy Mantle can no longer be re-rolled using an item like D4. Every so often it will come up and attempt to grab onto a random enemy in the room, holding them in place and dealing damage, The Worm Friend deals 4 damage for 8 ticks total, If the enemy moves quickly enough it can miss its attack, UNLOCK: Unlock this item by defeating The Beast as Apollyon, Enemies that die will leave behind 1-2 floating bone shards where they die, until you leave the room, Other enemies that touch the bone shards will take 3.5 damage, with a chance to either bounce off them or cause it to break and disappear, UNLOCK: Unlock this item by defeating Mother as The Forgotten, Each time an enemy dies, a friendly red soul appears. This includes all sources of damage, including environmental damage to enemies, Killing an enemy while berserk will increase the duration of the effect by 1 second, You don't die while in Berserk mode, but taking lethal damage will kill you after the effect wears off, The bone sword from this item is similar to Donkey Jawbone from Antibirth, Tainted Samson starts with a passive version of this item, UNLOCK: Unlock this item by defeating Delirium as Tainted Samson, Recharge time: Enemy damage taken = charge, When used, Isaac turns into a ghost for 1 second and his speed goes up to maximum (2.0). item room pool, red, boom, tnt, * item room, treasure room, item room pool, wooden, cross, brown, Isaac can now hold two trinkets at the same time, Drops a random trinket on the floor when picked up, Allows you to pick up more trinkets while also holding The Tick, * shop room pool, shop item pool, purple, pink, bag, All of Isaac's bombs now leave a poison effect on any enemies within the blast radius, As well as dealing the standard 60 damage for a bomb, it will apply a Damage over Time effect that does 4 or 6 damage per tick, Has a chance to drop from the Super Sloth miniboss fight. This is to prevent a syngery like Dr. Fetus or a Golden Bomb giving you infinite resources, Isaac's shadow will follow closely behind him and when it comes into contact with enemies, will spawn friendly dark charger mobs, The chargers deal contact damage to enemies, and will be killed if it is hurt too much, Chargers disappear upon entering a new room, UNLOCK: Unlock this item by beating Greed Mode with Judas, Every time you kill an enemy a fly will be added to the Jar, allowing you to stack up to 20, Using the Jar of Flies will release all the flies that are currently in the jar as friendly flies that will damage enemies, A Loki familiar that follows Isaac and shoots tears 4 tears in a cross pattern, dealing a flat 3.5 damage each, Gives Isaac a familiar glass of milk that follows him and spills on the floor upon taking damage, After being spilt, the milk gives you a -2 Tear Delay (Tears up) for the rest of the room, When used, the D7 will restart the current room and bring back all enemies once again, enabling you to farm rewards that spawn at the end after beating the room, Can be used to generate infinite consumable combinations, gaining as many coins/keys/bombs as you need, This item has no effect in Greed Mode, Challenge Rooms and rooms that had no enemies in originally, If used in a Boss Room or Angel/Devil Room, you get teleported to another random room, which is reset instead of the boss/angel/devil room you were in, Enemies respawned by the D7 don't drop loot if they were champions and also don't grant score in daily runs, * dice, pip, die, turban, white, grey, gray, Makes Isaac very small like a baby, reducing his hitbox size, When used, Mom's Box will drop a random trinket on the ground, While held, doubles the effect of trinkets which make sense to be doubled (e.g. Without any other multi-shot effect, the barrage size becomes 16/19/21 respectively. Effects This doesn't work with The Lost characters, While in a room with enemies, red cracks will appear on the floor in random locations, Walking over the crack spawns a white soul familiar, that launches itself into the nearest enemy, exploding and dealing double your tear damage to everything near it, Cracks will keep appearing but only one can exist in the room at a time, UNLOCK: Unlock this item by defeating challenge #38 (Baptism by Fire), While held, this item spawns a familiar that can be moved around using the arrow keys and deals 1.5 damage per tick to any enemies it touches, When activated, you teleport, swapping places with wherever Stitches was positioned, Teleporting next to fires will extinguish them (including blue fires) and on top of shopkeepers will destroy them (gives +10% devil/angel room chance as normal), If used while stitches is on top of an enemy, it can be used to telefrag enemies, dealing x3.5 your damage + 40, Can be used to enter/exit Curse Rooms for free by teleporting infront of the door while holding the direction key to move in immediately. Items Chapters Spawns another Vurp! With her weak blood and wheysour milk she had fed him and hid from sight of others his swaddling bands. The Lost starts with this item after donating 879 coins to the Greed Donation Machine. Based on the Steam Workshop mod (originally called Hungry Tears) created by Echo, UNLOCK: Unlock this item by taking 10 Tears Up items or pills in the same run, Isaac's tears are replaced with piercing holy flashes of light, which travel across the room in a similar speed to regular tears, Trisagion tears deal roughly 33% of your usual tear damage, however due to the size of the holy flash it is likely to hit enemies multiple times, Trisagion tears cause no knockback on enemies and simply travel through them (piercing tears), Added as part of the Afterbirth+ Booster Pack #4. Isaac's Heart Loki's Horns Bouncy Tears Homing Tears Tammy's Head Tiny Planet Tough Love The Wiz Incubus Epiphora Dead Eye Pupula Duplex Tractor Beam Evil Eye Dead Tooth Eye of Greed Glaucoma Eye of Belial Ghost Pepper Large Zit Rag Mega's Orbitals aren't affected by her shots. Unlocked from Challenge #24 - PAY TO PLAY, Power Pill - Gives you invulnerability and the ability to damage enemies for a short while (similar to The Gamekid effect), Re-Lax - Causes Isaac to spawn poops behind him while he walks for a few seconds. The laser deals damage equal to Isaac's damage and deals damage each tick. After the sword falls, extra items will no longer spawn, UNLOCK: Unlock this item by defeating The Lamb as Jacob & Esau, Upon use, spawns a giant puddle of lemonade that deals 8 damage per tick to any enemies which come in contact with it, Your tears are replaced with a sword which can be swung to deal damage (Damage * 3 + Base Damage). Dessert = +1 Flat Damage, +0.2 shot speed. It rerolls enemies and pickups it comes into contact with, then despawns. This video showcases all blood clot familiar variants that can be created with the Sumptorium item in The Binding of Isaac Repentance. Unlocked from Challenge #24 - PAY TO PLAY, Friends till the end - Spawns three friendly blue attack flies, Infested! blue, glow, 69, Isaac increases in size, gets a lion's mane and now has the ability to crush rocks by walking over them, Crushed rocks and poop can fill holes if you walk in their direction, Allows you to crush Red Poops and sometimes not take damage. The Knife Piece 1 is located in the Item Room in the mirrored area. Brimstone they called it raining down: the cities of the plain: Sodom, Gomorrah, Edom. He behaves the same as how Esau works with Jacob, following your exact movements, Disappears after the current room or if he takes enough damage and dies, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Forgotten, Creates 6 wisps, similar to the Book of Virtues effect, Mosts wisps will be the standard blue ones, but have a chance to have random special properties, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Bethany, Spawns Esau as a temporary familiar, who copies your exact movements the same as how the Jacob & Esau character works, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Jacob, Once picked up, you gain unlimited key use for the rest of the floor, Using a 'Bombs are Key' pill with this effect will swap your Gold Key for a Gold Bomb, Once picked up, you gain unlimited bomb use for the rest of the floor, Using a 'Bombs are Key' pill with this effect will swap your Gold Bomb for a Gold Key, UNLOCK: Unlock this item by beating challenge #23 (Blue Bomber), Fully charges your active item when picked up, Also, you take a full heart of damage when picked up. This chance doesnt change if you take further damage, You effectively have a 4.4% chance for every minute that passes after taking damage to die, Self-inflicted damage i.e. ), UNLOCK: Unlock this item by beating Blue Womb (Hush) with Cain, Gives Isaac a familiar golden Censer which creates a huge aura of light that slows down any enemies inside it, UNLOCK: Unlock this item by beating Greed Mode with Maggy, A familiar beggar similar to Bum Friend that follows Isaac and collects keys, giving random chests in return, UNLOCK: Unlock this item by beating Greed Mode with Lazarus, Item Pool: Item Room, Secret Room, Key Beggar, *, grey, gray, black, face, stone, rock, baby, A bag that follows Isaac and drops a random Rune or Soul Stone every 7 or 8 rooms, UNLOCK: Unlock this item by beating the Isaac boss with Lilith, A familiar angel which follows Isaac and fires Sacred Heart tears which deal 10 damage at -25% shot speed and a reduced fire rate, Item Pool: Item Room, Angel Room, Greed Mode Angel Room, This item causes enemy projectiles to be able to hit other enemies. Poison deals 5 damage initially and then 3.5, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Isaac, REPENTANCE - GB Bug is now a thrown projectile, activated by double tapping an attack button. - Speeds up all enemies for the rest of the room. On average . Additional copy of Monstro's Lung adds 3-5 more rings. Rotten Meat = +1 flat damage, +1.5 range. The effect is weaker than normal runes. Why? grey, gray, feet bobby bomb, When used, deals damage to Isaac in exchange for +1.2 damage up which lasts for the current room, The first use per room takes 1 full heart, then 0.5 hearts per use after that. Azazel: Overrides Azazel's Brimstone. Caves 2: 1 Boss Item + 2 Soul Hearts, Depths 1: 4 Soul hearts. The main purpose of the Cracked Key is to unlock Tainted character in the Home floor without needing to find the Red Key. purple, pink, mask, face, Puts a shield in front of Isaac which blocks projectiles, The shield will rotate based on the direction in which Isaac is firing tears, * angel room pool, god room pool, angel room item, blue, silver, metal, Gives Isaac a laser that will fire at random intervals in addition to your normal tears, Each laser does damage equal to your current tear damage, The laser will occasionally fire with one of these effects: Hook Worm, Spoon Bender, Tiny Planet, Mysterious Liquid, Rubber Cement, Luck has no effect on the rate at which Tech.5 fires and does not scale with items that increase your tears stat, UNLOCK: Unlock this item by beating Challenge #18 (The Host), * technology.5, tech 5, item room, treasure room, item room pool, white, red, eye, robot, Isaac now shoots two tears at once, but dealing -20% damage each, Unlike the Inner Eye and Mutant Spider items, this double shot item does not give a tears down, * 20 20, 2020, item room, treasure room, item room pool, black glasses, spectacles, Reveals the locations of the secret and super secret room for the current floor and all future floors, UNLOCK: Unlock this item by donating 10 pennies to the Shop, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, For Items it increases by 2 coins * the number of purchases. UNLOCK: Unlock this card by beating Challenge #12 (When Life Gives You Lemons), When used, will open all doors in the current room, similar to a one-time use of Dad's Key, UNLOCK: Unlock this card by beating Challenge #22 (Speed), When used this card will activate a use of your spacebar item for free, When used, this rune will destroy all breakable objects in the current room, such as poop, rocks, secret room entrances, UNLOCK: Unlock this card by beating Challenge #1 (Pitch Black), When used this rune will double all pickups on the floor in the room, Creates copies of pickups in the Shop which can be taken for free, even if you haven't purchased them yet, Can be used to double the number of item chests in the first room of the final Chest / Dark Room floors, Cloned chests have the same types of items as the first one, Cannot be used to clone trinkets or other Jera runes, UNLOCK: Unlock this card by beating Challenge #2 (High Brow), UNLOCK: Unlock this card by beating Challenge #3 (Head Trauma), Removes the curse which is in effect on the current floor (except Curse of the Labyrinth), Can also cure the effect of the Amnesia pill, UNLOCK: Unlock this card by beating Challenge #4 (Darkness Falls), When used, reveals the entire map including all the secret room locations and other icon rooms, UNLOCK: Unlock this card by beating Challenge #5 (The Tank), Rerolls all pedestal items in the current room (One time use of the D6), UNLOCK: Unlock this card by beating Challenge #6 (Solar System), Summons 3 blue friendly spiders and 3 blue flies, UNLOCK: Unlock this card by beating Challenge #20 (Purist), When used, gives you an invincibility effect which lasts for 20 seconds, UNLOCK: Unlock this card by beating Challenge #8 (Cat Got Your Tongue), When used, gives a random Mystic rune effect, Possible effects include: Algiz, Ansuz, Berkano, Dagaz, Ehwaz, Hagalaz, Jera, Perthro, Also has a 25% chance to spawn another Blank Rune upon use, UNLOCK: Unlock this card by beating Challenge #30 (Guardian), When used, this rune deals 40 damage to all enemies in the room and consumes all pedestal items in the room, giving you a random stat increase for each item consumed, Also consumes all pickups in the room and turns them into blue flies and spiders, UNLOCK: Unlock this item by beating Greedier mode as Apollyon. 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